The RAPID Project is a structured, multi-phase initiative aimed at improving the early identification of primary immunodeficiency disorders (PIDs) in Ukraine through a combination of clinical engagement and targeted diagnostics.
Key Components:
Multistage Approach:
- Organization of local clinical conferences for healthcare professionals.
- Follow-up field visits by pediatric immunologists for in-person evaluations and selective diagnostic sampling.
Selective Screening:
- Patients are pre-selected by primary care physicians, who are often the first to encounter early signs of recurrent infections in children.
Project Originators:
Anna Hilfanova, Yurii Stepanovskyi
Project Development Team:
Liudmyla Chernyshova, Yurii Stepanovskyi, Anna Hilfanova, Anastasiia Bondarenko, Stepan Beglaryan
Project Implementation Team:
Liudmyla Chernyshova, Yurii Stepanovskyi, Stepan Beglaryan, Anna Hilfanova, Anastasiia Bondarenko, Fedir Lapii
Supported by:
- Ministry of Health of Ukraine
- Shupyk National Healthcare University of Ukraine
- Department of Health, Chernihiv Regional State Administration
Project Objective:
To enhance early diagnosis of PIDs through two key methods:
- Direct collaboration with physicians and patient consultations
- Dissemination of information and awareness via media platforms
True Prevalence of Primary Immunodeficiencies (PIDs)
According to the International Patient Organisation for Primary Immunodeficiencies (IPOPI), the actual prevalence of PIDs is approximately 1 in 10,000 individuals, and when selective IgA deficiency is included — 1 in 500.
In contrast, the current documented prevalence of PIDs in Ukraine is approximately 1 in 100,000, which is ten times lower than expected.
Structure of the Screening Cycle
Stage 1:
Introduction to the project — an initial meeting between the patient association and local physicians to explain the purpose and methodology of the project.
Stage 2:
Formation of a target group of children — local physicians identify children with clear clinical indications for further evaluation by pediatric immunologists.
Stage 3:
Field assessment and testing — pediatric immunologists from Kyiv conduct on-site evaluations and collect biological samples for diagnostic testing.
Stage 4:
Data review and clinical follow-up — expert analysis of test results, clinical recommendations, and, if necessary, referral of patients to an immunology center for further management.
Project Pilot Region: Chernihiv Oblast
The pilot implementation of the RAPID Project was launched in Chernihiv Oblast, with a focus on collaboration between pediatric specialists and immunologists for early detection of primary immunodeficiencies (PIDs).
Project Timeline and Key Activities:
- April 5, 2017 – Chernihiv
Official project launch. Introductory meeting with district pediatricians during a regional Specialist Day. - April 26, 2017 – Chernihiv
First round of patient screening conducted by pediatric immunologists. - May 29, 2017 – Pryluky
On-site masterclass for local physicians followed by patient screening activities. - June 12, 2017 – Nizhyn
Educational session and masterclass on the identification of primary immunodeficiencies. - June 21, 2017 – Chernihiv
Additional screening visit by the pediatric immunology team to expand patient outreach.
Ongoing Monitoring
The project continues to operate on a scheduled basis. Future field activities and educational sessions will be communicated in advance.
Project Impact
For Patients:
- Access to early and accurate diagnosis
- Improved quality of life through timely intervention
- Prevention of life-threatening complications
For Medical Professionals:
- Enhanced diagnostic competencies
- Hands-on training through practical masterclasses
- Strengthened inter-specialty collaboration
For the Health System:
- Improved epidemiological insight into PID prevalence in Ukraine
- Optimized resource allocation for rare disease management